Publication:

Study of abnormal liver function tests in pregnancy in a tertiary centre in North Kerala

Background Abnormal liver function tests in pregnancy require proper evaluation and diagnosis. The underlying disorder can have a significant effect on the outcome of both mother and fetus. The present study was done with the objective to study the clinical profile, incidence and possible causes of derangements of liver function tests.

Methods The pregnant women with abnormal liver function were studied prospectively. All the liver function tests values were studied along with other required tests to identify the cause. The fetal and maternal outcome were also noted.

Results The incidence of abnormal liver function tests was 6.7%. Among these 96% were due to pregnancy specific liver dysfunction mainly due to hypertensive disorders. The mean value of bilirubin was more in infective hepatitis. There were 4 cases of intra uterine deaths and no maternal death.

Conclusions Pregnancy specific disorders are the major cause of abnormal liver function tests in pregnancy especially in the third trimester.