Publication:

A randomized controlled trial to compare the outcome of mechanically ventilated patients between daily interruption of sedation versus continuous sedation

Background This study is to Compare the Outcome of Mechanically Ventilated critically ill patients by daily interruption of sedation Versus continuous sedation.

Methods The proposed study was a double-blinded, prospective randomized control trial done in critically ill mechanical ventilator patients in the critical care units, for 14 months. 52 adult patients were equally divided into 26 into each group were receiving mechanical ventilation and continuous infusions of sedative drugs. The interruption Group of Patients are named As Group “I” Patients They Received Injection Midazolam Infusion of 2 mg Per Hour, And the Continuous Group patients named has Group “C” Was Received Injection: Midazolam infusion of 2 mg per hour in continuous infusion during the period of mechanical ventilation. The interruption Group of patients the sedative infusions were interrupted until the patients were awake, daily. Sedative infusions for the continuous group of patients in the intensive care unit were only interrupted at the clinician’s discretion.

Results The mean total duration of mechanical ventilation in hours (Group I) Interruption group is 79.46±28.96 while the mean total duration of mechanical ventilation in hours (Group C) continuous group is 174.26±84.91 The mean total number of hospitals stays in Group I is 16.42±3.12, while in Group C is 23.58±2.97.

Conclusions Due interruption of sedation infusions helps to periodically evaluate the neurological status and sedation score of the patients, it can able to assess the neurological status of the patient intermittently, and hence extubation can be planned earlier. Therefore, this study concludes that the reduced duration of Mechanical ventilation and length of stay in intensive care units were significantly reduced in interruption group.