Publication:

A comparative evaluation of intanasal salmon calcitonin and intravenous zolondrinic acid in the treatment of postmenopausal osteoporosis

Background Osteoporosis is a progressive disorder of the bones which is characterized by reduction in bone mass and increased risk of fractures. Various drugs are available for the treatment of osteoporosis and prevention of osteoporotic fractures. Zolindronic acid and salmon calcitonin are the first line of therapy among these. The aim of the study was to compare the effectiveness intanasal salmon calcitonin and intravenous zolondrinic acid the treatment of postmenopausal osteoporosisMethods: The study was conducted in the Department of Orthopaedics at a tertiary care centre from January 2015 to Jan 2017. One group received treatment with intravenous zolindronic acid 5mg administered as a single dose. Other group received a salmon calcitonin which was administered intranasally 100IU/day. Results were compared.

Results Total 80 patients were included in the study. Forty patients were allotted to each group. Mean T score of BMD of the patients in the salmon calcitonin group before the start of study was -3.38 and mean T score of the patients in the zolindronic acid group was -3.4. Which improved to -1.9 and -1.49 for the calcitonin group and zolindronic acid treated group respectively.

Conclusions Once yearly intravenous zolindronic acid is superior to intranasal salmon calcitonin in the treatment of post-menopausal osteoporosis.