Publication:

Primary diffuse large B-cell lymphoma of the nasal cavity: a rare aggressive entity

Lymphomas are heterogeneous malignancies that arise from the clonal proliferation of lymphoid cells at different stages of maturation. Non-Hodgkin’s lymphoma (NHL) often involves extranodal sites, such as the gastrointestinal tract, skin, bone, and brain. The most common subtype of NHL is diffuse large B-cell lymphoma (DLBCL), which has varied clinical and pathological findings depending on the primary site. DLBCL arising primarily from the nasal cavity is a rare and distinct entity, as it constitutes only 0.2-2% of all cases of NHL. It has a wide range of presentations from mild early-stage symptoms to severe forms in later stages. The symptoms are primarily due to the obstruction by the tumor mass. Caution should be given for early diagnosis and initiation of treatment, as it is an aggressive tumor and can extend rapidly to adjacent structures. Here, in this report, an unsuspected case of primary nasal cavity DLBCL in a 70-year-old male is described, demonstrating the unusual location of DLBCL and the significance of its accurate diagnosis and treatment.