Publication:

Autoimplantation therapy for the management of extensive molluscumcontagiosum: a novel treatment approach

Background Molluscumcontagiosum (MC) is a common cutaneous viral infection which usually affects children. Inspite of the multiple treatment options such as curettage, expression, electrodessication and different topical agents, in some cases lesions become extensive and persist for more than 3 to 4 years. The role of immunomodulatory therapy in management of MC has been well documented. Autoimplantation has emerged as a useful immunomodulatory therapy for warts. The objective of the study is to assess the efficacy and safety of autoimplantation in treatment of extensive MC.

Methods Patients of   either sex having more than six MC lesions were included. Molluscum body removed, crushed & implanted in a small dermal pocket as described in cases of warts. Patients were evaluated at four weeks, 12 weeks & subsequent 24 weeks.

Results Twenty two patients completed the study. Complete clearance of the MC was seen in 17 (77.2%) patients, 2 (9.1%) had no response, 1 (4.5%) had partial remission & 2 patients (9.1%) showed recurrence.

Conclusions Autoimplantation may be effective& alternative modalities for extensive MC. However, more randomized controlled trial for automplantation therapy in extensive MC need to be warranted.