Publication:

Central giant cell granuloma presenting as a multilocular radiolucency in the mandibular canine–premolar region: a pediatric case report

Central giant cell granuloma is a benign but locally invasive intraosseous lesion most commonly affecting the mandible in children and young adults. This report describes a 14-year-old female who presented with a firm, non-tender bluish swelling in the mandibular canine–premolar region. Radiographic examination revealed a well-defined multilocular radiolucent lesion with cortical expansion and divergence of adjacent teeth. Laboratory investigations showed normal calcium and parathyroid hormone levels, excluding hyperparathyroidism. Histopathological examination revealed multinucleated giant cells within a fibroblastic stroma, confirming the diagnosis of giant cell granuloma. The lesion was managed successfully with conservative surgical curettage and extraction of associated teeth. Overall, this case represents some aggressive behavior of central giant cell granuloma in a young female patient, demonstrating classic clinical, radiographic, and histopathological characteristics, and emphasizes the importance of systematic evaluation and surgical management.