Publication:

Correlation between glycemic control markers and lipid profile in type 2 diabetes mellitus and impaired glucose tolerance

Background Many studies have compared and correlated glycemic control markers with lipid profile in type 2 diabetes mellitus (T2DM) patients, but very few studies correlate them in impaired glucose tolerance (IGT) individuals. Thus, the aim of this study was to find comparison and correlation between FBG, PPBG and HbA1c with lipid profile in T2DM patients and IGT individuals.

Methods The study was conducted at tertiary care hospital in north Karnataka. The diagnosis of T2DM and IGT was based on WHO criteria. 99 apparently healthy controls, 101 T2DM patients and 100 IGT subjects participated in the study.

Results All the biochemical parameters were significantly raised in IGT and T2DM patients as compared to controls.In T2DM, FBG showed significant positive correlation with TC (p=0.048) and significant negative correlation with HDL (p=0.000). PPBG and HbA1c showed significant positive correlation with TGL, TC VLDL and LDL and significant negative correlation with HDL, p value was 0.000 for all parameters. The correlation in IGT, FBG showed significant positive correlation with TC (p=0.000) and LDL (p=0.004), significant negative correlation with HDL (p=0.000). PPBG showed significant positive correlation with TGL, TC and VLDL and significant negative correlation with HDL(p=0.000).

Conclusions Diagnosis of T2DM, IGT and associated dyslipidema is necessary as life style modification and pharmacotherapy can control these situations and thereby reduce the cardiovascular risk.