Publication:

Evaluation of anti-thyroglobulin antibodies and thyroid stimulating hormone level in cases of recurrent early pregnancy loss

Background Autoimmune thyroid disease (AITD) is by far the most frequent cause of hypothyroidism in women in reproductive age. The prevalence of hypothyroidism in the general population of reproductive age is 2-3%. The objective of this study was to evaluate maternal anti-thyroglobulin (ATG) concentrations and thyroid stimulating hormone (TSH) level in cases of recurrent miscarriage.

Methods 200 female patients divided into two groups. Group A: 100 female patients with history of recurrent miscarriage. Group B: 100 female patients with at least 2 living children and without history of recurrent early miscarriage.  Antithyroglobulin antibodies using chemilumeniscence immunoassay (normal level up to 115 IU/ml) and TSH level using chemilumeniscence immunoassay (normal level 0.350-2 U/ml) were assessed.

Results 8.0% of cases (n = 100) and 2.0% of control group (n = 100) were positive for anti TG antibodies. There was no significant relationship between the presence of anti TG antibodies and RPL (p = 0.052).  19% of cases (n = 100) were positive for TSH level. On the other hand, 14% of control group (n = 100) were positive for TSH level there was no significant relation between recurrent pregnancy loss and TSH, (P = 0.34).

Conclusions Neither TSH nor ATG showed significant difference in cases with recurrent miscarriage.