Publication:

Examining the relationship between chronic kidney disease, dyslipidaemia, and dysglycemia: a prospective study

Background Chronic kidney disease (CKD) results in profound lipid disorders, which stem largely from dysregulation of high-density lipoproteins (HDL) and triglyceride-rich lipoprotein metabolism. Objectives were to evaluate the correlation between chronic kidney disease, dyslipidaemia and dysglycemia.

Methods In-patient and outpatient department (OPD) of department of medicine, COM and JNM Hospital, Kalyani. Cases are defined as patients (>20 years of age) with a diagnosis of CKD (non-oedematous). The controls are defined as age and gender-matched patients (>20 years) attending medicine OPD/indoor without diagnosis of CKD.

Results Among the CKD cases, 30 individuals were diagnosed as overtly diabetic, whereas in the control group, 22 participants had fasting blood sugar (FBS) levels equal to or exceeding 126 mg/dl. The mean FBS was 111 mg/dl (standard deviation (SD) 44 mg/dl) in the CKD group and 91 mg/dl (SD 31 mg/dl) in the control group. The difference in FBS levels between the CKD patients' group and the control group was statistically significant (p value=0.001).

Conclusions Hyperglycaemia is also significantly associated with CKD in form of increased fasting blood sugar (47% among cases as compared to 30% in control) and increased post-prandial blood sugar (49% in cases as compared to 36% in controls). Dyslipidaemia occurs in CKD cases (39% among CKD cases and in 24% of controls) in the form of increased triglycerides (TG), LDL and low HDL.