Publication:

Anticonvulsant effect of Rosa damascena in pentylenetetrazole and maximal electroshock induced convulsions in albino rats

Background Rosa damascena mill L (Rosa damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated Anticonvulsant like effect of Rosa damascena in pentylenetetrazole (PTZ) and MES induced convulsions in albino rats.

Methods MES model: rats were divided into 4 groups of 6 rats each. Group-I received 0.5% normal saline, group-II (standard) received phenytoin 25 mg/kg, group-III ,IV received low dose (200 mg/kg) and high dose (400 mg/kg) of rosa damascena respectively orally convulsions were produced in all groups by giving maximum electric shock of 150 mA for 0.2 sec after 1 hour of giving test and standard drugs orally. Tonic clonic seizures were produced after giving electric shock .recovery time was noted. The percentage of inhibition of convulsions by drugs was measured and compared between the control, standard and test.PTZ model: rats were divided and test drugs were given same as above model but standard drug was sodium valporate (200 mg/kg). Convulsions were induced by giving the pentylenetetrazole IP 1hour after giving test and standard drugs intra-peritonelly. The onset of convulsions, duration of action and type of seizures were noted and compared between standard and test groups.

Results In MES Model, aqueous extract of Rosa damascena significantly (p<0.001) decreased the duration of tonic clonic seizures and recovery time. In PTZ model the onset of seizures was delayed (p<0.001) with low and high doses and the duration of convulsions was reduced effectively (p<0.001). Type of seizure was controlled in initial phase and number of seizures was also reduced.

Conclusions Rosa damascena was shown anticonvulsant property in both MES and PTZ animal models.