Case ReportInternational Journal of Research in Medical Sciences

Publication:
Primary systemic amyloidosis: a case report

Int J Res Med Sci. 2014;2(2):744-748.DOI10.5455/2320-6012.ijrms20140571

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Abstract

Primary amyloidosis is a group of monoclonal plasma cell disorders, characterized by extracellular deposition of immunoglobulin light chain fibrils in multiple organs leading to progressive multiorgan dysfunction. It is a rare disease which usually occurs in elderly persons and has a poor prognosis. We report a 72-year-old male patient with chronic abdominal distension, bilateral pitting pedal edema with nephrotic range proteinuria and amyloid deposition in liver and bone marrow. Immunoelectrophoresis of serum demonstrated the presence of immunoglobulin light chains of the circulating monoclonal protein. He was treated with IV bortezomib and IV dexamethasone.

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Affiliations

  1. Associate Professor, Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore - 560066, Karnataka
  2. Professor and Head, Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore - 560066, Karnataka
  3. Post graduate, Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore - 560066, Karnataka
  4. Professor, Department of Pathology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore - 560066, Karnataka
  5. Assistant Professor, Department of Medical Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore - 560066, Karnataka
  6. Associate Professor, Department of Medical Gastroenterology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore - 560066, Karnataka

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