Publication:

Pyrazinamide-induced acute gouty arthritis: a case report

Gout is a common inflammatory and metabolic disease caused by the deposition of monosodium urate crystals in articular and non-articular tissues. Drugs used to treat tuberculosis, such as pyrazinamide and ethambutol, have been linked to hyperuricaemia. However, acute gout is uncommon. We report a case of a 28-year-old female who developed acute gouty arthritis of the left knee joint as a result of taking pyrazinamide as part of a tuberculosis therapy regimen. Although pyrazinamide-induced hyperuricemia is frequently regarded as asymptomatic, the clinician should be aware of the likelihood of acute gouty arthritis, which can result in significant morbidity and an impaired quality of life.