Publication:

Microcompetition with latent Epstein-Barr virus causes a transcription factor deficiency, under-expression of retinoblastoma, and classic Hodgkin lymphoma

Classic Hodgkin Lymphoma (cHL) is characterized by the presence of Hodgkin/Reed-Sternberg (H/RS) cells, the malignant cells of the tumor.1 H/RS cells show two kinds of changes in their retinoblastoma (pRb) tumor suppressor, inactivation through hyper-phosphorylation of the protein, and low concentration caused by under-expression or over-degradation. This commentary concentrates on the under-expression option.