Publication:

Comparative evaluation of triglyceride/high density lipoprotein cholesterol and C-reactive protein between ischemic stroke and healthy control group

Background Triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) are predictive of the start of cardiovascular disease and metabolic syndrome. Dyslipidemia is a multifactorial disorder that exacerbates the vascular pathology associated with stroke. C-reactive protein (CRP) levels are elevated in people with a higher prevalence of stroke risk factors, such as hypertension, diabetes, and dyslipidemia. This study aims to compare and analyze the values of lipid ratio such as TG/HDL-C and inflammatory marker, CRP in acute ischemic stroke (AIS).

Methods This study was conducted at Jubilee Mission Medical College and Research Institute in Thrissur, Kerala. The duration of the research period was 2022 September to 2024 July. It was a prospective comparative cross sectional study. Data collection included physical, medical examinations and laboratory investigations. Statistical analysis was performed using statistical package for the social sciences (SPSS) version 26.

Results The comparison of inflammatory marker, CRP and lipid profile ratio such as TG/HDL-C showed an increased level in AIS than control. No correlation was observed between CRP and TG/HDL-C in AIS group.

Conclusions Our study observed that inflammatory markers especially CRP have strong predictive potential in diagnosing AIS. The lipid profile ratio such as TG/HDL-C have moderate predictive potential in AIS.