Original Research ArticleInternational Journal of Basic & Clinical Pharmacology
Publication: Evaluation of anticonvulsant activity of amlodipine in albino rats
Int J Basic Clin Pharmacol. 2017;6(3):664-668.DOI10.18203/2319-2003.ijbcp20170833
Abstract
Background The objective of the study was to evaluate the anticonvulsant activity of amlodipine in albino rats.
Methods Anticonvulsant activity of amlodipine was done in three graded doses (1 mg/kg, 2 mg/kg, 4 mg/kg), and combination group with low dose of amlodipine (1 mg/kg) and standard drug (phenytoin) in maximal electroshock seizures (MES) experimental animal model.
Results Amlodipine in dose of 2, 4 mg/kg showed dose dependent significant anticonvulsant effect and combination of low dose amlodipine and low dose of standard drug also showed significant anticonvulsant effect in MES model.
Conclusions Amlodipine is having anticonvulsant activity and also potentiated the anticonvulsant effect of phenytoin in MES model.
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Affiliations
- Department of Pharmacology, RVM Institute of Medical Sciences and Research Centre, Laxmakkapally, Mugulu, Medak, Telangana, India
- Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences, Adilabad, Telangana, India
- Department of Pharmacology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India