Publication:

C-reactive protein and Apo B as better predictor of STEMI than lipid profile

Background Total cholesterol, triglycerides, high density lipoprotein and low density lipoproteins are the recommended lipid variables for diagnosis and treatment of coronary artery disease. However, recent information shows the importance of apolipoprotein B and CRP as risk predictors of suspected CAD. Inflammation plays a major role in atherothrombosis and measurement of inflammatory markers such as CRP may provide a promising novel biochemical indicator for detecting individuals at high risk of plaque rupture.

Methods A total number of 43 cases of acute myocardial infarction with ST elevation myocardial infarction were included in this study. In this study CRP was elevated in more patients than LDL/HDL ratio (60.5% vs 20.9% respectively). Similarly, Apo B was elevated in more number of patients than LDL (72.1% vs 39.5% respectively). Also, Apo B/Apo A1 ratio was elevated in more number of patients than LDL/HDL ratio (51.2% vs 20.9% respectively).

Results In our study maximum incidence of ST elevation MI was present in age group 56-65 years with youngest of age 28 years and oldest of age 75 years. Out of 43 patients who suffered from STEMI 72.1% were males and only 27.9% were females. Out of 43 cases, 46.5% of cases had anterior wall MI, and 46.3% of the cases had inferior wall MI and only 9.3% of the cases developed anteroseptal wall MI. In our study death was encountered in only 9.3% (N – 4) of the cases.

Conclusions The results of the current study support the concept that the levels of apolipoprotein B, Apo B/Apo A1 ratio and CRP are strongly related to Coronary artery disease in addition to the conventional lipid profile.