Publication:

Anti-thyroid peroxidase antibody positivity and other obstetric complications in women with recurrent miscarriage

Background Thyroid dysfunction and autoimmunity are relatively common in women of reproductive age group and has been associated with various adverse pregnancy outcomes such as recurrent miscarriage, preeclampsia and preterm labour. The aim of this study was to find out association between anti-tpo antibody and recurrent miscarriage and to evaluate obstetric complications such as preeclampsia and preterm labour in them.

Methods This case control observational study was carried out from July 2014 to June2015 on 110 pregnant mothers out which 55 with history of recurrent miscarriage were cases and 55 without such history were controls.

Results The mean age of the cases were 24.18 yrs. Majority of pregnancy losses occurred between 9-14wks.The prevalence of anti-tpo antibody positivity in the study population was 15.45%.out of 55 cases 12 were positive for anti-tpo antibody(21.8%).Positive anti-tpo antibody was associated with high TSH level than the negative anti tpo antibody(p 2.5 but<10) and anti-tpo antibody can be suggested as these identify women with increased risk of miscarriage.