Publication:

A retrospective case series on midface augmentation using hyaluronic acid fillers and combination therapies

Mid-face volume loss from skeletal resorption, soft-tissue atrophy, and reduced dermal support is a key feature of facial ageing. Hyaluronic acid fillers such as Restylane® offer predictable, minimally invasive contour restoration. Combination approaches with adjunctive therapies may enhance results. This retrospective case series reviews individualized multimodal plans for mid-face augmentation using Restylane® fillers. 5 adults (3 males, 2 females; 35–50 years) presented with moderate-to-severe mid-face volume loss with malar hollowing, prominent nasolabial folds, and reduced cheek projection. Treatment plans combined Restylane® fillers (Lyft, Classyc, Defyne, Volyme, Vital) with energy-based devices, botulinum toxin A, and chemical peels, tailored to anatomical needs. Assessments used global aesthetic improvement scale, Medicis midface volume scale, and wrinkle severity rating scale. All patients showed improved contour and skin quality with no adverse events. Multimodal protocols integrating Restylane® fillers with complementary treatments provide effective, individualized mid-face rejuvenation. Prospective studies are needed to validate these findings.