Publication:

Estimation of life-time survival and predictors of mortality among the people living with HIV/AIDS: a case study in Andhra Pradesh, Indi

Background Antiretroviral treatment (ART) consistently improved survival of people living with HIV and contributes to prevent new infections. In this study, we estimated the life-time survival and examined the associated correlates of mortality amongst HIV-patients registered during 2007-11 in Andhra Pradesh, India.

Methods A total 63,882 adult HIV/AIDS cases (≥15 years) with complete follow-up information were extracted from ART database and included in the analysis. The Kaplan-Meier method was used to estimate the survival and Cox PH model was used to determine the relative hazard of mortality.

Results Nearly twelve percent (11.9%) of the total cases them (n=7,621) died during the follow-up period. Overall life-time survival was estimated to 12.2 (95% C.I. 12.0-12.3) years. Multivariable Cox proportional hazard model indicated the mortality was significantly associated with age, CD4 count, gender, clinical stage and functional status.

Conclusions The scale-up of ART has resulted in substantial reductions in mortality and increased survival. Such information is useful for institution of intervention measures to reduce risk of death.