Publication:

Levels of interluekin-6 and its correlation with maternal outcome in patients of gestational diabetes mellitus

Background Gestational diabetes mellitus (GDM) is a glucose tolerance disorder that occurs or is diagnosed for the first time during pregnancy. Objective was to see the levels of interluekin-6 and its correlation with maternal outcome in patients of gestational diabetes mellitus.

Methods The source of data for the study is the antenatal patients attending the Outpatient Department or admitted in “Upper India Sugar Exchange Maternity Hospital”, Department of Obstetrics and Gynaecology, G.S.V.M. Medical College, Kanpur. This study was a prospective study done on 120 patients.

Results Most patients in the study group belonged to the age group 20-24 years followed by age group 25-29 years. Level of interleukin-6 was significantly raised in gestational diabetes mellitus patients compared to non-gestational diabetes mellitus. 13.19% patients of GDM had PROM, which was only 6.5% in non GDM patients. 25.79% patients of GDM had preterm, which was only 12.8% in non GDM patients. 5.16% patients of GDM had polyhydramnios, which was only 2.64% in non GDM patients. 17.20% patients of GDM had IUGR, which was only 10.31% in non GDM patients.

Conclusions Gestational diabetes is associated with various maternal complications i.e. preeclampsia, preterm, PROM, IUGR, polyhydramnios, increased operative morbidity, development of type 2 DM.