Publication:

Association of false-positive quadruple test and adverse pregnancy outcomes

Background Aim of the study was to assess the relationship between false-positive quadruple test results and adverse pregnancy outcomes.

Methods This retrospective case-control study was analysed data from 600 pregnant women who underwent second-trimester screening. The study compared 100 women with false-positive results (high risk group) to 500 women with true-negative results (low risk group). Odds ratios (OR) and adjusted OR (aOR) for various adverse pregnancy outcomes were calculated and compared between the groups.

Results In this study, from 600 pregnant women in 2 groups. Some associations between high-risk group and adverse pregnancy outcomes can be found. The adjusted odds of developing gestational hypertension were significantly higher in the false-positive group (aOR 2.36, 95% CI: 1.07-5.18). Similarly, the risk of having a newborn with a low birth weight was also higher in this group (aOR 2.77, 95% CI: 1.06-7.24). No significant differences were observed between two groups regarding the rates of preeclampsia, gestational diabetes, fetal growth restriction and preterm labor.

Conclusions Women with a false-positive quadruple test result have an increased risk of developing gestational hypertension and delivering a low-birth-weight newborn.