Publication:

The study of correlation of silent myocardial ischemia with microalbuminuria in patients of type 2 diabetes mellitus

Background Diabetes is a common and serious disease leading to chronic, mostly irreversible macro and microvascular complications.

Methods 50 Patients, attending Diabetic OPD at SGRD hospital, Amritsar. Asymptomatic patients with no symptoms or history of IHD and normal ECG with microalbuminuria were enrolled in the study. A complete clinical examination was done.

Results The prevalence of microalbuminuria increased with worsening glycemic control, as evidenced by prevalence of 74 % in patients with HbA1c of more than 9 percent. The prevalence of microalbuminuria increased with the duration of diabetes, as evidenced by prevalence in 48 % in patients, with duration of diabetes of more than 11 years. The prevalence of microalbuminuria increased with increased in BMI, as evidenced by prevalence of 56 % in overweight Patients. The prevalence of microalbuminuria increased in patients of Diabetic Retinopathy, as evidenced by prevalence of 82 % in patients of Diabetic Retinopathy. In the present study, 70.8 % patients with duration of diabetes in the range 11-15 years had positive treadmill test.

Conclusions Hence, in this study it was observed that longer the duration of diabetes with microalbuminuria, greater is the predisposition for silent myocardial ischemia. In the present study, 64 % of asymptomatic patients with microalbuminuria had a positive treadmill exercise test. Hence, we deduce from this study that microalbuminuria is an independent risk factor for silent myocardial ischemia.