Publication:

Misoprostol versus Dinoprostone for induction of labour in premature rupture of membranes

Background To compare the efficacy of misoprostol (PG E1 analog) and Dinoprostone (PGE2) for induction of labour in patients with premature rupture of membranes (PROM).

Methods This prospective study was conducted at the Department of Obstetrics and Gynaecology, Dr. BVP Rural medical college, Loni, Ahmednagar, Maharashtra. A total of 120 women (60 in each group) presenting with PROM (premature rupture of membranes) within 48 hours with gestational age between 34 weeks to 40 weeks were included. Group A women received tab misoprostol 25 mcg orally and Group B women received Dinoprostone gel vaginally kept in posterior vaginal fornix for induction of labour. Dose was repeated every 4th hourly in Group A with maximum of 4 doses and it was repeated 6th hourly In Group B with maximum of 3 doses.

Results Among 60 patients in Group A, 47 (78.33%) delivered vaginally and 13 (21.66%) were delivered by caesarean section. In Group B, 39(65%) patients delivered vaginally and 21(35%) were delivered by LSCS.

Conclusions Oral misoprostol 25 mcg 4 hourly is efficient and cost-effective alternative to PGE2 gel for cervical ripening and induction of labour in PROM patients.