Original Research ArticleInternational Journal of Reproduction, Contraception, Obstetrics and Gynecology
Publication: Evaluation of the relationship between thyroid hormones and endometriosis: a clinical investigation
Int J Reprod Contracept Obstet Gynecol. 2025;14(9):2846-2852.DOI10.18203/2320-1770.ijrcog20252708
Abstract
Background Endometriosis is a chronic gynecological condition that affects reproductive-aged women. This study evaluated the correlation between thyroid hormone levels and endometriosis severity.
Methods A cross-sectional study was conducted at Shohada Tajrish Hospital and Atieh Hospital from September 2024 to April 2025. Participants diagnosed with endometriosis underwent clinical, ultrasound, and thyroid hormone assessments. Statistical analyses were used to explore correlations between hormone levels and endometriosis severity.
Results Significant associations were found between anti-TPO levels and UBESS stage 2. Pain severity was higher in moderate disease. However, TSH, T3, and Free T4 levels showed no significant correlations with disease stage or pain severity. Adhesion levels were associated with nodule presence and uterosacral ligament thickness.
Conclusions Elevated anti-TPO levels may indicate autoimmune involvement in moderate endometriosis. Structural markers on ultrasound, such as nodule count and USL thickness, may predict disease severity.
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Affiliations
- Department of Radiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Department of Gynecology and Laparoscopy, Atieh Hospital, Tehran, Iran
- Department of Medical Genetics, Faculty of medical Sciences, Tarbiat Modares University, Tehran, Iran
- Department of Radiology, Shohahada Hospital, Tehran, Iran
- Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America