Publication:

Conception rate of intrauterine insemination in a subfertile population cervical factor, mild male factor, unexplained infertility in tertiary care centre

Background Intrauterine insemination (IUI) is a widely used assisted reproductive technique for subfertile couples, particularly those with cervical factor, mild male factor, or unexplained infertility. Despite its popularity, the effectiveness of IUI across different etiologies remains debated.

Methods This observational study was conducted at the department of obstetrics and gynecology, Government Medical College and Hospital, Akola, Maharashtra. Subfertile women were categorized based on etiology- cervical factor, mild male factor, or unexplained infertility- and underwent IUI following standard ovulation induction protocols. Primary outcomes included conception rate per cycle and cumulative pregnancy rate. Secondary outcomes assessed endometrial thickness, follicular response, and cycle characteristics.

Results IUI yielded variable conception rates across etiological groups. Women with cervical factor infertility demonstrated the highest conception rates, followed by those with unexplained infertility and mild male factor. Favourable endometrial thickness and monofollicular development were associated with higher pregnancy rates. The number of cycles required for conception was lowest in the cervical factor group.

Conclusions IUI remains a cost-effective and minimally invasive first-line treatment for selected subfertile populations. Cervical factor infertility responds most favorably to IUI, while mild male factor and unexplained infertility show moderate success. Careful patient selection and individualized stimulation protocols enhance outcomes.