Publication:

Yoga as a therapeutic modality for hormonal and metabolic regulation in premenopausal women with polycystic ovary syndrome

Background Polycystic ovary syndrome represents a significant health challenge for women during the premenopausal phase, characterized by hormonal imbalances, metabolic dysfunction, and chronic inflammation. Traditional pharmacological approaches often provide incomplete relief and may be associated with unwanted side effects. This investigation examined yoga practice as a non-pharmacological therapeutic strategy for addressing the multidimensional pathophysiology of PCOS.

Methods Forty premenopausal women aged 35-55 years diagnosed with PCOS participated in this three-month randomized controlled investigation at GVN Hospital, Trichy, Bangalore. Participants were allocated to control (n=10) and yoga intervention (n=30) groups. The yoga protocol consisted of structured 30-minute sessions held three times per week, incorporating physical postures, breathing techniques, and meditation. Comprehensive assessments included reproductive hormone profiles, inflammatory biomarkers, metabolic parameters, and clinical outcomes.

Results Participants engaging in yoga interventions demonstrated substantial improvements across multiple physiological domains. Significant reductions were observed in high-sensitivity C-reactive protein and interleukin-6 levels, indicating decreased systemic inflammation. Hormonal assessments revealed favorable changes in luteinizing hormone, estradiol, and prolactin concentrations. Metabolic indices showed improvement, with enhanced insulin sensitivity and reduced markers of metabolic dysfunction. Enhanced pregnancy rates were observed among participants seeking conception.

Conclusions A structured 12-week yoga intervention effectively modulates hormonal balance, reduces inflammatory burden, and improves metabolic health in premenopausal women with PCOS. These findings support yoga as a valuable complementary therapeutic approach that addresses multiple pathophysiological aspects of the syndrome, offering a holistic, sustainable, and patient-centered management strategy for women with PCOS.