Publication:

Incidence of preeclampsia and fetal growth restriction among antenatal women with normal uterine artery Doppler at 11-14 weeks

Background Preeclampsia remains a leading contributor to maternal morbidity and mortality worldwide, while fetal growth restriction is associated with an increased risk of adverse neonatal outcomes, including preterm birth, low birth weight, and long-term developmental challenges. Early prediction and prevention of these conditions are crucial for improving maternal and fetal outcomes. This study aims to estimate the incidence of preeclampsia and fetal growth restriction in antenatal women with normal uterine artery Doppler at 11-14 weeks.

Methods A prospective observational study for a period of one and a half year, clinical data and demographic data were collected, analysed and the p-value will be calculated by the Pearson Chi-square test. The significance level will be set a p<0.05.

Results Despite normal uterine artery Doppler indices at 11–14 weeks, the study population showed a 7.3% incidence of preeclampsia and 36% fetal growth restriction. These women also had higher risks of small-for-gestational-age neonates, gestational hypertension, and diabetes. Maternal age, body mass index (BMI), socioeconomic status, education, and parity were significantly associated with adverse outcomes, and fetal growth restriction was notably linked to preeclampsia.

Conclusion The study highlights that even with normal uterine artery Doppler PI at 11–14 weeks, women remain at risk for preeclampsia and fetal growth restriction. Early identification and monitoring, including aspirin therapy and attention to borderline PI values, may help prevent adverse outcomes. The findings support further research combining Doppler with biochemical markers for improved early prediction.