Publication:

Evaluation of serum paraoxonase level and dyslipidemia in psoriasis

Background Psoriasis is a chronic recurrent inflammatory skin disorder that is associated with oxidative stress, altered lipid metabolism and with high risk of cardiovascular events. High density lipoprotein (HDL) bound serum paraoxonase enzyme exhibits anti-atherogenic properties. It protects against the development of coronary heart disease by preventing low density lipoprotein (LDL) oxidation. The aim of our work was to evaluate the serum paraoxonase levels and dyslipidemia in psoriasis.

Methods Present study involved 100 participants of which 50 were diagnosed cases of psoriasis and 50 were age and sex matched healthy controls, who fulfilled inclusion criteria. Serum paraoxonase (PON), and lipid profile were estimated in cases and controls. Lipid profile was estimated by using autoanalyser EM 200 and serum paraoxonase by spectrophotometric method.

Results Patients presented risk changes in lipid profile [(increase in triglycerides (p=0.005), low density lipoprotein cholesterol (p=0.009), very low density levels (p=0.002) and a reduction in high density lipoprotein cholesterol (p≤0.001)] which were highly significant when compared to controls. Serum paraoxonase levels was decreased in psoriasis patient compared to control which was statistically highly significant (p= 0.001).

Conclusions Present data suggest that psoriasis patients must be considered as a group at risk for cardiovascular disease.