Publication:

Mixed connective tissue disease presenting with isolated pulmonary hypertension, and limited cutaneous sclerosis

Mixed connective tissue disease (MCTD) was first recognized by Sharp and Colleagues in 1972 among a group of patients with overlapping clinical features of systemic lupus erythematosis (SLE), scleroderma and myositis, with the presence of distinctive antibodies against, what now is known to be U1ribonucleoprotein (RNP). We report an unusual case of a 29-year old female with MCTD characterized by the coexistence of signs, symptoms and immunological features of 3 defined autoimmune diseases isolated PHT, cutaneous sclerosis (SSc), hypothyroidism.