Publication:

Effect of telmisartan on acute model of inflammation in male Wistar rats: an experimental study

Background The objective of the study was to investigate the influence of telmisartan on acute model of inflammation in adult male Wistar rats.

Methods After obtaining ethical clearance from Institutional Animal Ethics Committee, animals were allotted to the three groups i.e. control, aspirin and telmisartan (n=6 animals in each group). The effect of telmisartan, administered orally, on inflammation was studied using acute (Carrageenan induced rat paw edema) model. Experiment was conducted according to the Committee for the purpose of Control and Supervision of Experiments on Animals (CPCSEA) guidelines. Analysis was done using one way ANOVA followed by post hoc tests of Dunnet’s and Bonferroni’s. P < 0.05 was considered as statistically significant.

Results Telmisartan, used orally in the present study, showed significant anti-inflammatory activity in acute model of inflammation.

Conclusions In view of role of inflammation in the pathogenesis of atherosclerosis and their complications, treatment by telmisartan can reduce complications by virtue of its anti-inflammatory activity, in addition to its antihypertensive effect. Also this study may help to open new avenues for therapeutic indications of telmisartan.