Publication:

The levels of testosterone, zinc, manganese and selenium in type 2 diabetic patient in South-Eastern Nigeria

Background This study is aimed at evaluating the levels of some trace elements and testosterone, and to ascertain their possible association in type 2 diabetes mellitus.

Methods Ninety male type 2 diabetic subjects and forty five apparently healthy non-diabetic male individuals were recruited into this study. The control group was matched for age with the study subjects and they were all within the age range of 30-67 years. Fasting Plasma Glucose (FPG), testosterone, trace elements (zinc, selenium, manganese), Body Mass Index (BMI) were determined.

Results This study showed significant decreases in the levels of trace elements (Zn, Se, and Mn) with a concomitant decrease in the levels of testosterone in type 2 diabetic patients (P <0.001). This findings were further strengthened by the strong positive correlation between testosterone and these trace elements (P <0.05).

Conclusion This suggests that low testosterone level might be as a result of low trace elements considering their role in testosterone production. Therefore, trace elements supplementation is recommended.