Publication:

Study of analgesic effect of septilin in comparison with aspirin and tramadol in experimentally induced pain in rats

Background The task of medicine is to preserve and restore health and to relieve suffering. pain is the most common symptom that brings a patient to a physician's attention. There are many NSAIDs and opioid analgesics which have been employed for alleviating pain but none is free from side effects and drug interactions. Therefore search for a new potent, safe and non toxic drug continues.

Methods This animal study was a cross sectional, observational in nature carried out in male Wistar rats. Animals were divided into four groups with six animals in each group. Group I, II, III, IV given normal saline (control), Tab. Septilin (test), Tab. Aspirin (standard 1),Tab. Tramadol (standard2) respectively through oral feeding tube and tested for thermal reaction time on Eddys hot plate at different time intervals. Reaction times had been recorded and evaluated by using one way ANOVA followed by Tukey’s post hoc test with the help of Graph pad Prism. The ‘P’ value of <0.05 was considered significant.

Results The test group (Septilin- 500mg/kg) has shown increase in mean reaction time which is higher, when compared to control group and the increase in mean reaction time of test drug is less when compared to standard groups (Aspirin-100mg/kg and Tramadol- 2mg/kg), but is significant i.e. P value <0.05 at 30, 60, 120 min time intervals. Based on the aforementioned findings septilin has analgesic effect but less than that of the standard drugs Aspirin and Tramadol.

Conclusions The test drug Septilin has analgesic effect, but less when compared to Standard drugs Aspirin and Tramadol. To obtain the final assessment, large scale clinical trials may be necessary to prove its efficacy and further use of Septilin in a routine medical practice.