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Preliminary study on antiulcer effect of agomelatine and its potentiation with pyridoxine

Background Agomelatine is a synthetic analogue of melatonin and a potent agonist of melatonin receptors. Agomelatine has Hepatoprotective as well as antioxidant activity. The aim of study was to evaluate the antiulcer activity of Agomelatine and its potentiation through the pyridoxine on ethanol induced gastric ulcer in rats.

Methods Thirty number of rats were divided in to five groups contro, standard, Agomelatine low dose, Agomelatine high dose and Agomelatine with Pyridoxine groups. Ethanol was used to induced gastric ulcer in rats. ulcer index and also the other biochemical parameters like free Acidity, total Acidity, gastric pH, volume of gastric juice was determined. Statistically analysis was done by ANOVA P value less than 0.05 was considered Statistically significant.

Results In the present study, an attempt has been made to investigate the gastric antisecretory, antiulcer and cytoprotective properties of agomelatine. The results are statistically significant by ANOVA test. Ranitidine showed a statistically significant decrease in the volume of gastric juice by free acidity and total acidity. when compared to control. Agomelatine shows a showed similar response to the volume of gastric juice. A significant difference in pH was observed between the agomelatine-treated, agomelatine with pyridoxine treated group and the control groups.

Conclusions Pretreated rats with Agomelatine (40mg/kg) showed protective effect against ethanol induce gastric ulcer. Agomelatine (40mg/kg) showed the ameliorative effect with Pyridoxine (0.3mg/kg), on gastric ulcer.