Publication:

Study of biochemical markers in iron deficiency anemia

Background The present study was aimed to study alterations in levels of oxidants and antioxidants in iron deficiency anemia (IDA).

Methods 30 patients of IDA in age group of 20-50 and 30 healthy subjects were included for study. Serum Iron, TIBC & Hb% were estimated to diagnose IDA. Serum Malondialdehyde (MDA), Nitric oxide (NO) as an oxidants & Superoxide dismutase (SOD), vitamin E, vitamin C, Zinc (Zn) levels as antioxidants were estimated.

Results Significant decreased levels of Hb%, serum iron, SOD, Vitamin C, vitamin E, Zn were found. TIBC, MDA, NO were significantly increased as compared to controls.

Conclusion The normal adult erythrocytes can resist oxidative stress by several antioxidant defense systems. In IDA, oxidative stress causes lipid peroxidation and membrane damage. So antioxidants can be used as a marker for prevention of membrane damage due to oxidative stress.