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Anti-ulcer effect of rhizome of Curcuma longa Linn, by the method of pyloric ligation

Background Substantial part of the world population has been known for a long time to suffer from peptic ulcer disease. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its anti-ulcer properties.

Methods The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxhlet extraction with 50% ethanol. Albino rats of Wistar strain (120-200 grams) obtained from the animal house of medical college Thiruvananthapuram were used. Ranitidine was collected from Kerala Sate Drugs and Pharmaceutical LTD Alapuzha. Antiulcer study in rats were done using the method of pyloric ligation.

Results Antiulcer study in rats using the method of pyloric ligation, extract of Curcuma longa in 1000mg/Kg dose levels exhibited significant protection against shay ulceration. The results were comparable to that of standard drug Ranitidine.

Conclusions The present study with extract of Curcuma longa revealed that it has significant anti-ulcer activity.