Publication:

Assessment of serum IgE level in patients with transfusion related allergic reaction receiving fresh frozen plasma

Background Blood transfusion is a routine lifesaving medical intervention which is generally regarded as safe when done properly. However, at the same time it also bears considerable risk. The aim of the study was to assess the serum IgE levels in patients experiencing transfusion-related allergic reactions after receiving fresh frozen plasma.

Methods This cross-sectional observational study was conducted at the Department of Transfusion Medicine, BSMMU, from March 2019 to August 2021, focusing on patients aged 5 to 60 years receiving fresh frozen plasma. Patients were included after obtaining informed consent from themselves or their legal guardians in the case of minors, according to the eligibility criteria. Data were analyzed using SPSS version 26, with statistical significance set at p<0.05, employing Chi-square tests and Pearson’s correlation coefficient for variable comparisons.

Results Raised IgE level was significantly related with transfusion related allergic reaction after receiving fresh frozen plasma (p<0.05). The mean IgE was 521.4±434.6 in patients with reaction and 67.8±33.2 in patients without reaction. Significant positive correlation was observed in serum IgE level with age in years.

Conclusions Patients with transfusion related allergic reaction receiving fresh frozen plasma had higher mean IgE levels as compared to those without reaction.