Publication:

A cross-sectional study of thyroid dysfunction in patients of chronic kidney disease in Goa medical college

Background Thyroid hormones are essential for regulating metabolism, development, protein synthesis, and other hormone functions. CKD has been linked to changes in the pituitary-thyroid axis and peripheral thyroid hormone metabolism.

Methods A cross-sectional study was conducted in 100 subjects from September 2019 to September 2021 in the department of medicine, Goa Medical College, a tertiary care hospital in Goa.

Results Most of the CKD patients in study population are in the Age group of 41-70 years. 70% were male. 54% patients were diabetic and 46% patients were non diabetic, majority of them 87% patients were hypertensive, majority of them were DM and HTN With 88% and few patients belonged to other diseases. 8% patients with high TSH level, 6% with low TSH level, 86% with normal TSH level. TT4 levels were low in 28% patients and normal in 72% patients, TT3 levels were high in 3% patients, low in 60% and normal in 37% patients. FT4 levels were high in 5% patients and low in 7%, normal in 88% patients. FT3 levels were high in 1% patients, low in 49%, normal in 50% patients. 55% patients belong to euthyroid state and 7% patients belongs to hypothyroid state and 36% patients belong to sick euthyroid state and 2% belongs to subclinical thyrotoxicosis.

Conclusions Most of the participants in this study were euthyroid. The most common thyroid hormone derangement was low T3 values (non-thyroidal illness). The prevalence of hyperthyroidism in this study was 2% and hypothyroidism 7%.