Review ArticleInternational Journal of Research in Medical Sciences

Publication:
Role of adipose tissue in people with obesity and its relationship with the appearance of metabolic diseases

Int J Res Med Sci. 2025;13(2):911-916.DOI10.18203/2320-6012.ijrms20250281

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Abstract

The alteration of adipose tissue plays a fundamental role in the appearance of chronic inflammation diseases; insulin resistance, lipid deposition in obese patients. In recent years it has been shown that under the stimulation of adipocytes in stressful situations, their endoplasmic reticulum generates a response that over activates the inflammatory response of adipose tissue and interferes with normal mentalism, generating the secretion of adipokines, affecting the thermogenic pathways of the tissue. adipose, which causes the manifestation of metabolic syndrome. This article summarizes the relationship between adipocyte endoplasmic reticulum and adipose tissue dysfunction in obese patients.

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Affiliations

  1. School of Medicine, UDLA University, Quito, Ecuador
  2. Department of Medicine, Armed Forces Hospital, Pastaza, Ecuador
  3. Ministry of Public Health, Quito, Ecuador
  4. Department of Medicine, Armed Forces Specialty Hospital, Quito, Ecuador
  5. IPS ARTMEDICA, Medellín, Colombia
  6. Intensive Care Unit Department, Ecuadorian Institute of Social Security, Ambat, Ecuador

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