Publication:

Study of histopathological spectrum in various prostatic lesions in transurethral resection of prostate specimen

Background The prostate is an organ located retroperitoneally that surrounds the neck of the bladder and urethra. The majority of instances of prostatic disease are caused by benign prostatic hyperplasia (BPH), followed by prostatic adenocarcinoma. Transurethral resection of prostate (TURP) is required to detect prostatic abnormalities. Purpose of this study was to examine histomorphological spectrum of prostatic lesions in TURP specimen.

Methods Total 150 TURP specimens were studied which were received during September,2022 to July 2023 at Universal pathology laboratory, a private laboratory. Sections of typical lesional tissue and gross findings were observed in all received TURP specimen. Haematoxylin and eosin (H&E) stained slides were examined. Following histological assessment, tumors were classified according to WHO recommendation, and histological grading was done using modified Gleason system.

Results A total 150 TURP specimens were studied were included 145(96.66%) non-neoplastic and 5 (3.33%) to be cancerous (Table no.2). Among the benign lesions, Benign Prostatic Hyperplasia (BPH) 116 cases, BPH+ Chronic prostatitis 21 cases, BPH+ basal cell hyperplasia 4 cases, Granulomatous prostatitis 1 case, Atypical adenomatous hyperplasia 3 cases and 4 cases of malignant lesions were observed.

Conclusions TURP plays a significant role in the diagnosis of prostatic lesions. The benign lesions are more common than malignant ones. The modified Gleason score is applied for prostatic cancer, which is simple and accurate to grade these malignancies.