Publication:

The impact of NAFLD on diabetic complications in patients with T2DM

Background This study investigates the relationship between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, focusing on the associated macrovascular and microvascular complications. The aim is to assess the impact of the temporal sequence of these conditions on patient outcomes.

Methods An observational study was conducted over three months (October 2023 to December 2023) at Katihar Medical College, enrolling 91 patients diagnosed with type 2 diabetes and NAFLD. Participants were grouped based on the duration of NAFLD and type 2 diabetes, and a range of clinical, laboratory, and diagnostic assessments were conducted to evaluate macrovascular and microvascular complications. Statistical analyses were performed to compare the groups.

Results The study found that Group C had significantly higher BMI, WHR, triglycerides, ALT, AST, γ-GT, and uric acid levels compared to Groups A and B. The prevalence of CAD and hypertension was significantly higher in Group C. Group B had a longer NAFLD duration and higher ALT and AST levels than Group A. These findings suggest a strong association between metabolic dysfunction, NAFLD, and diabetic complications.

Conclusion The study concludes that the temporal sequence of NAFLD and type 2 diabetes significantly influences the prevalence of macrovascular complications, particularly coronary artery disease and hypertension, in affected patients.