Publication:

Hesperidin in dentistry: a natural flavonoid with promising therapeutic potential: a narrative review

Hesperidin, a flavonoid primarily found in citrus fruits has garnered attention in biomedical research for its potential to inhibit demineralization, enhance remineralization, antimicrobial properties, anti-inflammatory effects, regenerative properties and wound healing. Flavonoids also possess collagen-crosslinking effects and dentin collagen proteolytic degradation inhibition property. Hesperetin (HS), a metabolite of hesperidin, is a polyphenolic component of citrus fruits. This ingredient has a potential role in bone strength and the osteogenic differentiation. This review aims to summarize current evidence regarding the application of hesperidin in various dental disciplines, highlighting its mechanisms of action, clinical relevance and future research prospects. More researches and studies are required in this regard to use them in our daily clinical practices.