Publication:

A rare case of membranous nephropathy with crescent who responded to intravenous cyclophosphamide

Crescent formation is a rare complication of primary membranous nephropathy. It is a sign of severe glomerular injury and can lead to rapid deterioration of renal function. Primary membranous nephropathy and crescents have a lower remission rate and poor prognosis. Crescentic transformation can be associated with ANCAs or anti-GBM antibodies. Early detection and prompt management reduces the chances of progression to end stage kidney disease. Authors hereby report a case of primary membranous nephropathy with crescent who had negative ANCA and anti-GBM antibodies who responded to cyclophosphamide and achieved stabilization of GFR.