Publication:

Aggressive NUT carcinoma presenting as a nasal mass: a rare case report

Nuclear protein in testis (NUT) carcinoma is an exceptionally uncommon and highly aggressive carcinoma, refractory to treatment and has a devastating clinical course. NUT gene is expressed in non-germ cell tissues along with chromosomal rearrangement of the NUT gene on chromosome 15. These tumors are most commonly located in midline and near midline areas of the upper aero digestive tract and the mediastinum and can affect patients across a broad age range, including children. However, due to its low incidence, this is often misdiagnosed by the clinicians and pathologists. Here, we present a case report of NUT carcinoma in a 45- year- old female coming with chief complaints of nasal bleeding and nasal obstruction. This case report emphasizes the critical role of histopathological examination, supplemented by immunohistochemical analysis, in establishing a definitive diagnosis and underscores the diagnostic challenges posed by sinonasal undifferentiated tumors.