Publication:

A comparative clinical study on efficacy of terbinafine and griseofulvin in patients with tinea corporis

Background The objective of the present study was to compare the efficacy of terbinafine and griseofulvin in patients with tinea corporis in a tertiary care hospital, Madurai.

Methods About 60 patients are selected from the outpatient department of Dermatology according to inclusion and exclusion criteria. They were divided into 2 groups of 30 patients each. Group 1 received tab. terbinafine 250 mg OD and group 2 received 250 mg BD for 4 weeks. All patients were investigated at baseline, end of 2nd week and at end of 4 weeks. Effectiveness of both the drugs were determined by achieving clinical as well as mycological cure. The results were recorded, tabulated and analysed using student’s t test.

Results Patients in group 1 showed higher clinical and mycological cure rate when compared with group 2.

Conclusions Oral terbinafine is the effective antifungal agent in the treatment of extensive tinea corporis infection.