Original Research ArticleInternational Journal of Basic & Clinical Pharmacology
Publication: Analgesic, anti-inflammatory and antipyretic activities of ethanol extract of Annona senegalensis leaves in experimental animal models
Int J Basic Clin Pharmacol. 2020;9(10):1477-1484.DOI10.18203/2319-2003.ijbcp20204084
Abstract
Background This study was carried out to establish the analgesic, anti-inflammatory and antipyretic effects of the ethanol extract of Anonna senegalensis leaves in experimental animals.
Methods The analgesic activity was measured using the abdominal constriction and tail flick tests. The anti-inflammatory activity was performed using xylene and egg-albumen paw induced tests, while the antipyretic activity was measured using brewer’s yeast and 2, 4 dinitrophenol induced pyrexia tests, respectively.
Results The leaf extract at all doses used exhibited significant (p<0.05) analgesic, anti-inflammatory and antipyretic activities.
Conclusions Results show that ethanol leaf extract of Anonna senegalensis possess therapeutic potential against pains and feverish conditions, supporting the claims of its this plant as remedy for similar ailments.
Keywords
Affiliations
- Department of Optometry, School of Health Technology, Federal University of Technology, Owerri, Nigeria
- Department of Pharmacology and Therapeutics, College of Health Sciences, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
- College of Medicine, Chukwuemeka Odumegwu Ojukwu University, Amaku, Awka, Nigeria
- Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria
- Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Nigeria
- Department of Internal Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Nigeria