Publication:

Thyroxine replacement by colonic route and absorption kinetics: case report

In the literature there are only 2 reports of replacement of thyroid hormones by colonic route. The objective of this study is to present a clinical case where thyroid hormone replacement was performed through the application of enemas with levothyroxine. 78-year-old patient with hypothyroidism is presented who attended to the emergency room with intestinal occlusion, which presented refractory hypothyroidism secondary to intestinal occlusion and she underwent hormone replacement with enemas with levothyroxine. The kinetics of colonic absorption of thyroid hormones takes twice as long to reach the plateau of serum levels with respect to absorption in jejunum and ileum.