Publication:

A case report of zoledronic acid-induced bilateral conjunctivitis

Zoledronic acid is used to treat patients with osteoporosis, Paget’s disease, multiple myeloma, and several bone tumors. This is to report a case of a patient with cervical spondylosis with periorbital swelling, watering, diminution of vision, and redness in both eyes after zoledronate infusion. The patient had lid edema and conjunctival congestion in both eyes. Symptoms resolved after 10 days of fluorometholone eye drops. Bilateral conjunctivitis is a rare complication of zoledronic acid. Zoledronic acid causes T-cell activation leading to the release of cytokines and inflammatory mediators. Orbital inflammation, scleritis, and acute anterior uveitis have also been reported as side effects of zoledronic acid.