Publication:

Exploring the relationship between coagulation profiles and histopathological diagnosis of breast lumps: a case control study from Vindhya region, India

Background Breast cancer is the most common cancer among women in India. The country is on the verge of a potential breast cancer epidemic in the coming decade, driven by lifestyle changes such as delayed marriage and childbirth, influenced by Western trends. Hypercoagulable state is one of the adverse complication seen in cases of breast cancer, according to recent study. Therefore, the purpose of this study was to evaluate the coagulation anomalies in breast cancer patients.

Methods The study was a prospective, case control study carried out with patients presenting with complaints of lump in the breast which were confirmed to be malignant by histopathological examination.

Results Values of PT and aPTT were found to be comparable in patients with breast cancer when compared with controls. D-Dimers were found to be significantly elevated in patients with breast cancer when compared with controls. D-Dimers were also elevated in cases with high histological grade of cancer and lymphovascular invasion.

Conclusions Elevated levels of plasma D-dimer may offer some insight for the diagnosis breast lump.