Publication:

Squamous cell carcinoma arising from immature teratoma of the kidney in a patient with chronic pyelonephritis

Renal squamous cell carcinoma (SCC) is a rare malignancy often associated with chronic renal conditions like pyelonephritis and nephrolithiasis. Malignant transformation of a renal immature teratoma into SCC is exceedingly rare. We report a case of a 27-year-old male presenting with chronic pyelonephritis and left flank pain. Imaging revealed a renal mass, and subsequent nephrectomy with histopathology confirmed SCC arising from an immature teratoma, with regional lymph node metastasis. Chronic inflammation may have contributed to malignant transformation. This case highlights the potential for malignancy in renal teratomas and the need to consider SCC in patients with chronic renal pathology for timely diagnosis and management.