Publication:

Efficacy of platelet rich plasma gel vs conventional dressing in chronic non-healing wounds: a randomized controlled trial

Background Chronic non-healing wounds pose significant clinical and economic challenges. This study evaluates the efficacy of platelet-rich plasma (PRP) gel against conventional dressings in chronic wound management.

Methods A single-center, open-label randomized controlled trial included 138 patients with chronic wounds (≥3 months duration). Participants were divided into PRP gel (n=69) and conventional dressing (n=69) groups. Outcomes included healing time, wound size reduction, pain scores, complications and follow-up visits.

Results PRP-treated wounds achieved complete healing faster (60.87% within 5–8 weeks vs. 34.78% in controls, p<0.001) with fewer complications (scarring: 8.70% vs. 36.23%, p<0.001). PRP reduced follow-up visits (mean: 5.94 vs. 33.16, p<0.001). Pain scores were comparable except transient discomfort during PRP application.

Conclusions PRP gel accelerates healing, minimizes complications and reduces healthcare burden, making it superior to conventional dressings for chronic wounds.